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XML generation date: 2024-09-20 06:23:28.831
Product last modified at: 2024-08-15T23:00:08.148Z
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PDP - Template Name: Chemical Modulators
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  1. Products /
  2. Activators & Inhibitors /
  3. A23187 (Calcimycin)

A23187 (Calcimycin) #23911

    Product Information

    Product Usage Information

    A23187 (Calcimycin) is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 0.64 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 523.6 g/mol
    Purity >98%
    Molecular Formula C29H37N3O6
    CAS 52665-69-7
    Solubility Soluble in DMSO at 25 mg/mL or ethanol at 5 mg/mL.

    Background

    The calcium ionophore A23187 (Calcimycin) is an antibiotic that induces Ca2+-dependent cell death by increasing intracellular concentrations of calcium ions. It is a commonly used biochemical and pharmacological tool due to its multiple, unique biological effects (1). A23187 treatment of murine embryonic fibroblasts and human colon cancer cells induced autophagy in both cell lines (2). Anti-microbial A23187 strongly inhibits Mycobacterium bovis BCG growth in vitro and in THP-1 cells by regulating intracellular calcium and inducing autophagy (3). A23187 treatment of HL-60 cells triggers increased intracellular levels of Ca2+, generation of both intracellular and extracellular reactive oxygen species (ROS), and induction of apoptotic cell death (4). An increase in ROS is also seen in A23187-treated rat neonatal cardiac myocytes and in murine and human platelets accompanied by platelet particle formation (5,6). A23187 treatment can activate oocytes and produce normal embryos in cases of dysfunctional oocyte activation caused by insufficient Ca2+ release from the endoplasmic reticulum (6).

    Limited Uses

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    Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

    For Research Use Only. Not For Use In Diagnostic Procedures.
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