ABT-263 (Navitoclax) #79381
Product Information
Product Usage Information
ABT-263 (Navitoclax) is supplied as a lyophilized powder. For a 5 mM stock, reconstitute 5 mg of powder in 1.0 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
Storage
Product Description
| Molecular Weight | 974.6 g/mol |
| Purity | >98% |
| Molecular Formula | C47H55CIF3N5O6S3 |
| CAS | 923564-51-6 |
| Solubility | Soluble in DMSO at 25 mg/ml. |
Background
ABT-263 (Navitoclax) is a potent and orally bioavailable Bcl-2 family inhibitor. This small molecule mimetic of BH3 domains specifically binds to Bcl-2, Bcl-xL, and Bcl-W with a Ki value of less than 1 nM (1). ABT-263 (Navitoclax) has been shown to have antitumor effects on small cell lung cancer (SCLC) xenograft models, resulting in complete tumor regression in some cases (2). Studies have shown that ABT-263 (Navitoclax) can enhance the effectiveness of chemotherapeutic and targeted agents against solid tumors (3). ABT-263 (Navitoclax) induces apoptosis, particularly in certain types of senescent cells (4,5).
Limited Uses
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