ABT-737 #93584
Product Information
Product Usage Information
Storage
Product Description
| Molecular Weight | 813.4 g/mol |
| Purity | >98% |
| Molecular Formula | C42H45ClN6O5S2 |
| CAS | 852808-04-9 |
| Solubility | Soluble in DMSO at 5 mg/mL. |
Background
ABT-737 is a BH3 mimetic that is a potent inhibitor of multiple Bcl-2 family members, including Bcl-xL, Bcl-2, and Bcl-w that all have a Ki value of less than or equal to 1 nM (1,3). ABT-737 binds to these anti-apoptotic Bcl-2 family members and inhibits their interaction with pro-apoptotic BH3-domain proteins, leading to Bax-Bak mediated apoptosis. ABT-737 has cytotoxic activity in multiple cancer types, including small-cell lung cancer and lymphoid malignancies (2,3). It has also been shown to inhibit and regress tumor growth in xenograft tumor mouse models (3).
Limited Uses
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