Render Target: STATIC
Render Timestamp: 2025-01-21T11:10:52.555Z
Commit: da7e4f2f0d1aed1f1f8e20e4e2ecab8f33cbd595
XML generation date: 2024-09-20 06:23:15.360
Product last modified at: 2025-01-01T09:02:29.792Z
1% for the planet logo
PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72

Adavosertib #69589

Adavosertib: Image 1
Chemical structure of Adavosertib.

To Purchase # 69589

Cat. #

Size

69589S
5 mg

Product Information

Product Usage Information

Adavosertib is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 999 μL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight 500.6 g/mol
Purity >98%
Molecular Formula C27H32N8O2
CAS 955365-80-7
Solubility Soluble in DMSO at 70 mg/mL.

Background

Adavosertib (MK-1775) is a potent, selective Wee1 kinase inhibitor with an IC50 value of 5.2 nM. Adavosertib inhibits phosphorylation of the Wee1 substrate Cdc2 at Tyr15, thereby abrogating the G2 DNA damage checkpoint (1). Wee1 inhibition in p53-deficient tumors by Adavosertib has been shown to inhibit and regress tumor growth (2).
For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
All other trademarks are the property of their respective owners. Visit our Trademark Information page.