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XML generation date: 2024-09-20 06:23:31.089
Product last modified at: 2024-08-30T22:30:08.719Z
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72

AK-7 #36804

    Product Information

    Product Usage Information

    AK-7 is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.14 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at room temperature, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 437.4 g/mol
    Purity >98%
    Molecular Formula C19H21BrN2O3S
    CAS 420831-40-9
    Solubility Soluble in DMSO at 50 mg/mL or ethanol at 8 mg/mL.

    Background

    The brain-permeable small-molecule AK-7 inhibits the NAD-dependent deacetylase sirtuin 2 (SirT2) which is involved in cytoskeletal regulation and progression through mitosis. The inhibitor AK-7 specifically binds and inhibits SirT2 (IC50 = 15.5 mM) and has no apparent effect on SirT1 or SirT3. AK-7 reduced total cholesterol in primary striatal neurons and reduced cholesterol in cultured naïve neuronal cells and brain slices from wild-type mice (1). Treatment with AK-7 improved motor function, extended survival, and reduced brain atrophy in a pair of genetic mouse models of Huntington’s disease (2). In a study of aging in a rat model of Parkinson's disease, AK-7 inhibition revealed a potential role for SirT2 in Parkinson's neurodegeneration, and suggested that AK-7 may have a beneficial neuroprotective effect (3). Similar results were seen in a mouse model of Parkinson's disease, but AK-7 was not able to counteract neurodegenerative processes associated with amyotrophic lateral sclerosis (ALS) or cerebral ischemia (4).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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