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XML generation date: 2024-04-24 09:10:45.190
Product last modified at: 2024-10-22T12:00:15.391Z
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72
  1. Products /
  2. Activators & Inhibitors /
  3. Ascomycin (FK520)

Ascomycin (FK520) #31403

    Product Information

    Product Usage Information

    Ascomycin (FK520) is supplied as a lyophilized powder. For a 5 mM stock, reconstitute 5 mg of powder in 1.26 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 792 g/mol
    Purity >99%
    Molecular Formula C43H69NO12
    CAS 104987-12-4
    Solubility Soluble in DMSO at 50 mg/ml or ethanol at 50 mg/ml with slight warming.

    Background

    Ascomycin (FK520) is a 23-membered macrolide lactone produced from the fermentation of Streptomyces hygroscopicus (1). A natural analogue of FK506, Ascomycin (FK520) has the ability to bind to FK506-binding protein 12 (FKBP12), inhibiting calcineurin phosphatase activity, and disrupting the activation of nuclear factor of activated T cells (NFAT) and other various substrates (2). Primarily described as an antifungal antibiotic, Ascomycin (FK520) has shown to be a potent immunosuppressant (IC50 = 0.55 nM) used to prevent the rejection of organ transplants and skin allografts (1,3). Ascomycin (FK520) displays powerful antimalarial properties independent of its immunosuppressive mechanisms of action (2).

    Limited Uses

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    Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

    For Research Use Only. Not For Use In Diagnostic Procedures.
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