BC-11-38 #82556

Name: BC-11-38
Price: 132.00 USD
Availability: InStock

Product Information

Product Usage Information

BC-11-38 is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 1.10 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at room temperature, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight	304.4 g/mol
Purity	>98%
Molecular Formula	C₁₅H₁₆N₂OS₂
CAS	68770-80-9
Solubility	Soluble in DMSO at 50 mg/mL or ethanol at 14 mg/mL.

Background

The small-molecule BC-11-38 is an inhibitor of dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 (PDE11), which catalyzes hydrolysis of the second messengers cyclic guanosine 3', 5'-monophosphate (cGMP) and cyclic AMP (cAMP) in intracellular signaling regulation. BC-11-38 is a selective and potent inhibitor of PDE11, displaying IC₅₀values of less than 330 nM for PDE11 and a greater than 100-fold selectivity for PDE11 relative to other PDE isozymes. BC-11-38 treatment of human adrenocortical cells inhibited PDE11 and resulted in increased cAMP levels, cAMP-dependent protein kinase (PKA) activity, and cortisol production (1,2). At the time of its identification, BC-11-38 was thought of as a potential therapeutic target for the treatment of renal insufficiency (3).

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.

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