BRD-7389 #99734

Name: BRD-7389
Price: 132.00 USD
Availability: InStock

Product Information

Product Usage Information

BRD-7389 is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 0.91 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight	366.4 g/mol
Purity	>98%
Molecular Formula	C₂₄H₁₈N₂O₂
CAS	376382-11-5
Solubility	Soluble in DMSO at 35 mg/mL.

Background

The inhibitor BRD-7389 was originally isolated by screening a set of small molecules for detection of insulin protein production in a murine pancreatic α-cell line. BRD-7389 treatment of cells resulted in a dose-dependent increase in Ins2 mRNA and a number of β-cell markers. Similar results were seen in primary human islet cells. Further studies determined that BRD-7389 inhibited a number of protein kinases, and was most active against 90 kDa ribosomal S6 kinase (RSK) family members, with IC₅₀ values of 1.5 mM, 2.4 mM, and 1.2 mM for RSK1, RSK2, and RSK3, respectively (1). BRD-7389 inhibited RSK activity and blocked cell proliferation in colon cancer cells stimulated by muscarinic acetylcholine receptor activation (2). BRD-7389 and the unrelated RSK inhibitor BI-D1870 inhibited protein synthesis and cell proliferation in multiple dual-resistant melanoma patient-derived cells, suggesting a possible strategy in the treatment of drug-resistant melanoma (3).

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.

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