Bromosporine #97061
Product Information
Product Usage Information
Bromosporine is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.23 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
Storage
Product Description
| Molecular Weight | 404.4 g/mol |
| Purity | >98% |
| Molecular Formula | C17H20N6O4S |
| CAS | 1619994-69-2 |
| Solubility | Soluble in DMSO at 25 mg/ml. |
Background
Bromosporine is a potent broad-spectrum bromodomain inhibitor (1). Bromodomain and extra-terminal (BET) protein family members BRD2, BRD3, BRD4, and BRDT associate with acetylated lysines on histones and transcription factors to regulate their function, and have emerged as targets for cancer therapy (2,3). Treatment with Bromosporine induced the expression of latent HIV-1 in primary CD4+ T cells by inhibiting BET activity, leading to improved viral clearance in conjunction with antiretroviral therapy (4).
Limited Uses
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