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Render Timestamp: 2024-11-21T13:58:27.219Z
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XML generation date: 2024-09-19 21:57:43.333
Product last modified at: 2024-11-01T19:15:08.334Z
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72

Camostat Mesylate #42819

    Product Information

    Product Usage Information

    Camostat Mesylate is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 10 mg of powder in 1.34 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 494.5 g/mol
    Purity >98%
    Molecular Formula C20H22N4O5 • CH3SO3H
    CAS 59721-29-8
    Solubility Soluble in DMSO at 50 mg/ml or water at 50 mg/ml.

    Background

    Camostat Mesylate, also known as Foipan or FOY 305, is a synthetic serine protease inhibitor that is often used to treat pancreatitis pain (1). Camostat Mesylate attenuates airway epithelial sodium channel (ENaC) function by inhibiting channel-activating proteases (CAPs) with an IC50 of 50 nM (2). Camostat Mesylate inhibition of trypsin decreased food intake, body weight, blood glucose, liver weight, and lipidosis and increased FGF21 expression in obese mice (3).

    Camostat Mesylate is an effective inhibitor of TMPRSS2, a serine protease used by SARS-CoV-2/COVID-19 for viral S-protein priming and cell entry. Pre-treatment of human lung cancer cells with 100 μM Camostat Mesylate significantly reduced COVID-19 viral entry (4).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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