Captopril #53537
Product Information
Product Usage Information
Captopril is supplied as a lyophilized powder. For a 20 mM stock, reconstitute 5 mg of powder in 1.15 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
Storage
Product Description
| Molecular Weight | 217.3 g/mol |
| Purity | >98% |
| Molecular Formula | C9H15NO3S |
| CAS | 62571-86-2 |
| Solubility | Soluble in DMSO at 20 mg/ml or water at 20 mg/ml. |
Background
Captopril is a selective and reversible angiotensin-converting enzyme (ACE) inhibitor with an IC50 value of 0.022 μM (1). This small molecule selectively lowers angiotensin II, a hormone that when upregulated has been linked to increased hypertension, atherosclerosis, myocardial hypertrophy, and obesity (2-5). Captopril has also been shown to regulate inflammatory pathways as a reversible inhibitor of leukotriene A4 (LTA4) hydrolase, reducing leukotriene B4 synthesis (6).
- Fujita, H. and Yoshikawa, M. (1999) Immunopharmacology 44, 123-7.
- Bolterman, R.J. et al. (2005) Hypertension 46, 943-7.
- Vajapey, R. et al. (2014) Front Physiol 5, 439.
- Wu, C. et al. (2011) N Am J Med Sci (Boston) 4, 183-90.
- Putnam, K. et al. (2012) Am J Physiol Heart Circ Physiol 302, H1219-30.
- Orning, L. et al. (1991) J Biol Chem 266, 16507-11.
Limited Uses
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