Doxorubicin #5927
Product Information
Product Usage Information
Storage
Product Description
| Molecular Weight | 579.98 g/mol |
| Purity | >99% |
| Molecular Formula | C27H29NO11 • HCl |
| CAS | 25316-40-9 |
| Solubility | Soluble in DMSO at 100mg/ml and H2O at 10mg/ml. |
Background
Doxorubicin, an anthracycline antibiotic, inhibits DNA and RNA synthesis in mammalian cells and has been shown to be a very effective anti-tumor agent (1,2). Doxorubicin binds to nucleic acids by intercalating the DNA double helix and stabilizing topoisomerase II cleavage complexes, leading to DNA strand breaks at specific doxorubicin-induced sites (3). Doxorubin has been shown to inhibit DNA synthesis in a dose-dependent manner in MCF7 cells, which corresponds closely with growth inhibition (4). Researchers have also demonstrated that doxorubicin effectively inhibits human DNA topoisomerase I (5).
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