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XML generation date: 2024-09-20 06:23:28.335
Product last modified at: 2024-10-22T17:45:09.818Z
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PDP - Template Name: Chemical Modulators
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  1. Products /
  2. Activators & Inhibitors /
  3. Dynasore

Dynasore #46240

    Product Information

    Product Usage Information

    Dynasore is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 1.03 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 322.3 g/mol
    Purity >98%
    Molecular Formula C18H14N2O4
    CAS 304448-55-3
    Solubility Soluble in DMSO at 30 mg/mL or ethanol at 1 mg/mL.

    Background

    Dynasore is a cell-permeable, small-molecule inhibitor of the endocytosis-associated GTPase dynamin (IC50 = 15 mM). Dynamin promotes clathrin-coated vesicle formation and is involved in detaching coated pits from the membrane during clathrin-mediated endocytosis. Dynasore inhibits the GTPase activity of dynamin I, dynamin II, dynamin-related protein 1, and mitochondrial dynamin. By blocking dynamin, Dynasore inhibits coated vesicle formation and dynamin-mediated endocytic pathways (1). In a study of hippocampal synapses, inhibition by Dynasore demonstrated that dynamin is essential for all forms of synaptic vesicle endocytosis, and that Dynasore has no effect on exocytosis (2). A study of hepatocellular carcinoma demonstrated that Dynasore enhanced the inhibitory effects of c-Met inhibitors on hepatoma cell proliferation and migration, and led to increased cell cycle arrest and apoptosis (3). Dynasore blocked HSV-1 entry into human and murine keratinocytes, and prevented HSV-1 and HSV-2 infection of human epithelial and neuronal cells, including primary genital tract cells and human fetal neurons and astrocytes (4).

    Limited Uses

    Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.

    Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

    For Research Use Only. Not For Use In Diagnostic Procedures.
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