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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72
  1. Products /
  2. Activators & Inhibitors /
  3. Echinomycin

Echinomycin #51434

    Product Information

    Product Usage Information

    Echinomycin is supplied as a lyophilized powder. For a 1 mM stock, reconstitute 1 mg of powder in 0.91 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 1101.3 g/mol
    Purity >98%
    Molecular Formula C51H64N12O12S2
    CAS 512-64-1
    Solubility Soluble in DMSO at 5 mg/mL.

    Background

    The small-molecule Echinomycin is an inhibitor of hypoxia-inducible factor 1 (HIF1), an important transcription factor controlling the expression of genes that facilitate the response to a hypoxic environment. Cellular response to hypoxia involves angiogenesis, erythropoiesis, cell cycle, metabolism, and apoptosis, all of which are important for metastasis and tumor progression. Echinomycin inhibits HIF-1α and HIF-1β binding to a hypoxia-responsive element sequence of promoters of hypoxia-responsive genes (1). Echinomycin eliminated the ability of mouse lymphoma and human acute myeloid leukemia (AML) cancer stem cells to form colonies, and inhibited human AML in a xenogeneic model through preferential elimination of cancer stem cells (2). Inhibition of HIF-1α by Echinomycin can reduce the effects of acute graft-versus-host disease and extend leukemia free survival following allogeneic hematopoietic stem cell transplantation (3). Echinomycin inhibited adipogenesis and suppressed adipocyte differentiation in 3T3-L1 WAT preadipocytes, which may lead to a new therapeutic approach targeting obesity and diabetes (4).

    Limited Uses

    Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.

    Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

    For Research Use Only. Not For Use In Diagnostic Procedures.
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