Gö6976 #12060
Product Information
Product Usage Information
Gö6976 is supplied as a lyophilized powder. For a 1 mM stock, reconstitute the 500 µg in 1.32 ml DMSO. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used as a pretreatment at 0.1-10 µM for 0.5-1 hr prior to treating with a stimulator or is used alone with varying treatment times lasting up to 24 hr. Soluble in DMSO at 25 mg/ml; very poorly soluble in ethanol and water with maximum solubility in water at ~1-5 µM.
Storage
Product Description
| Molecular Weight | 378.4 g/mol |
| Purity | >99% |
| Molecular Formula | C24H18N4O |
| CAS | 136194-77-9 |
| Solubility | Soluble in DMSO at 25mg/ml. |
Background
- Martiny-Baron, G. et al. (1993) J Biol Chem 268, 9194-7.
- Gschwendt, M. et al. (1996) FEBS Lett 392, 77-80.
- López-Bergami, P. et al. (2005) Mol Cell 19, 309-20.
- Wen, J. et al. (2011) J Neuroinflammation 8, 38.
- Lemonnier, J. et al. (2004) J Biol Chem 279, 259-64.
- Chung, Y.W. et al. (2011) J Biol Chem 286, 29681-90.
- Paruchuri, S. and Sjölander, A. (2003) J Biol Chem 278, 45577-85.
- Grandage, V.L. et al. (2006) Br J Haematol 135, 303-16.
- Behrens, M.M. et al. (1999) J Neurochem 72, 919-24.
Limited Uses
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