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Product last modified at: 2024-07-08T23:00:08.522Z
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PDP - Template Name: Chemical Modulators
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  1. Products /
  2. Activators & Inhibitors /
  3. Lenalidomide

Lenalidomide #90543

    Product Information

    Product Usage Information

    Lenalidomide is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 1.29 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Caution: Teratogenic. Pregnant women should avoid using compound.

    Storage

    Store lyophilized at room temperature, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 259.2 g/mol
    Purity >98%
    Molecular Formula C13H13N3O3
    CAS 191732-72-6
    Solubility Soluble in DMSO at 30 mg/mL.

    Background

    The immunomodulatory drug Lenalidomide is one of a number of chemically modified analogs of the angiogenesis inhibitor, Thalidomide. Lenalidomide can act as an anti-tumor agent by suppressing angiogenesis and activating the immune system (1). Binding of Lenalidomide to Cereblon (CRBN), a substrate receptor for the CRL4 E3 ubiquitin ligase, causes selective ubiquitination and degradation of the zinc finger transcription factors Ikaros and Aiolos (2). A similar mechanism leads to the ubiquitination and targeted degradation of casein kinase 1α (CK1α) (3). Lenalidomide also downregulates SALL4, a zinc finger transcription factor that has been implicated in some human malformation syndromes, including Duane-radial ray syndrome (Okihiro syndrome) and Acro-renal-ocular syndrome (4). Lenalidomide (and other Thalidomide derivatives) can effectively treat multiple myeloma, mantle cell lymphoma, and non-Hodgkin follicular lymphoma (5-7) and can effectively induce remission in patients with myelodysplastic syndrome, either with or without chromosome 5q deletion (8).

    Limited Uses

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    Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

    For Research Use Only. Not For Use In Diagnostic Procedures.
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