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Product last modified at: 2024-12-17T19:02:56.840Z
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MCC-950 (sodium salt) #86428

    Product Information

    Product Usage Information

    MCC-950 (sodium salt) is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.17 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 426.5 g/mol
    Purity >98%
    Molecular Formula C20H23N2O5S • Na
    CAS 256373-96-3
    Solubility Soluble in DMSO at 40 mg/ml or water at 30 mg/ml.

    Background

    MCC-950 (sodium salt), also known as CRID3, is a potent and selective NOD-like receptor (NLR) family pyrin domain-containing protein 3 (NLRP3) inhibitor. NLRP3 is an inflammasome-forming NLR that activates caspase-1, leading to maturation of IL-1β and IL-18 (1). MCC-950 (sodium salt) inhibits IL-1β production in mouse bone marrow-derived macrophage (BMDM) cells with an IC50 value of 7.5 nM (2). The NLRP3 inflammasome is involved in different diseases such as Parkinson’s disease (PD), multiple sclerosis (MS), type 2 diabetes, and atherosclerosis, making MCC-950 (sodium salt) an important compound when studying different autoinflammatory and autoimmune diseases (2,3).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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