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XML generation date: 2024-09-20 06:23:28.581
Product last modified at: 2024-05-30T07:19:00.558Z
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PDP - Template Name: Chemical Modulators
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  1. Products /
  2. Activators & Inhibitors /
  3. MHY1485

MHY1485 #17949

    Product Information

    Product Usage Information

    MHY1485 is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 0.86 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at room temperature, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 387.4 g/mol
    Purity >98%
    Molecular Formula C17H21N7O4
    CAS 326914-06-1
    Solubility Soluble in DMSO at 20 mg/mL or DMF at 10 mg/mL.

    Background

    MHY1485 is a small, synthetic compound that activates the molecular mammalian target of rapamycin (mTOR) (1). mTOR is a Ser/Thr protein kinase that functions as an ATP and amino acid sensor to balance nutrient availability and cell growth. Cellular mTOR is a core component of both mTORC1 and mTORC2 multiprotein complexes, which regulate cell growth, proliferation, motility, and survival, as well as transcription, protein synthesis, and autophagy (2). Treatment of rat hepatocytes with MHY1485 suppressed autophagy by activating mTOR and inhibiting the fusion of autophagosomes and lysosomes (1). MHY1485 activated the mTOR-Nrf2 signaling pathway in UV-treated skin cells, preventing cell death and apoptosis. The mTOR activator suppressed UV-induced reactive oxygen species production and DNA single-strand breaks in UV-treated skin keratinocytes and fibroblasts (3). Similar treatment with MHY1485 rescued cultured osteoblasts from the cytotoxic effects of dexamethasone exposure, and increased ovarian weights, restored endocrine function, and promoted primordial follicle development in mice (4,5).

    Limited Uses

    Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.

    Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

    For Research Use Only. Not For Use In Diagnostic Procedures.
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