Nafamostat Mesylate #38695
Product Information
Product Usage Information
Nafamostat Mesylate is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 10 mg of powder in 1.23 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
Storage
Product Description
| Molecular Weight | 539.6 g/mol |
| Purity | >98% |
| Molecular Formula | C19H17N5O2 • 2CH3SO3H |
| CAS | 82956-11-4 |
| Solubility | Soluble in DMSO at 50 mg/ml or water at 50 mg/ml. |
Background
Nafamostat Mesylate, also known as FUT-175, is a potent and reversible, broad-spectrum serine protease inhibitor of trypsin (Ki = 15 nM), tryptase (Ki = 95.3 pM), and other additional proteases (1). This small compound has been identified as a key player in the disruption of the inflammatory response via inhibition of the complement system and coagulation cascade (2). Its wide range of inhibitory activity displays anti-cancer and anti-viral properties and has shown effective inhibition of MERS-CoV by preventing membrane fusion, making it a promising therapeutic candidate against the 2019-nCoV infection (EC50 = 22.50 μM) (3,4).
Limited Uses
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