Necrostatin-1s #17802

Name: Necrostatin-1s
Price: 88.00 USD
Availability: InStock

Product Information

Product Usage Information

Necrostatin-1s is supplied as a lyophilized powder. For a 20 mM stock, reconstitute 5 mg of powder in 900 μl of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at room temperature, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight	277.7 g/mol
Purity	>98%
Molecular Formula	C₁₃H₁₂CIN₃O₂
CAS	852391-15-2
Solubility	Soluble in DMSO at 25 mg/ml.

Background

Necrostatin-1s, also known as Nec-1s or 7-Cl-O-Nec-1, is a potent and selective inhibitor of necroptosis. This analog of Necrostatin-1 (Nec-1) has been shown to be a specific receptor-interacting protein kinase (RIPK) 1 inhibitor that is metabolically more stable than the other variants (1). Research studies have found that Nec-1s is more selective than Nec-1 and Nec-1i (inactive variant) due to the fact that both molecules have an inhibitory affect on indoleamine 2,3-dioxygenase (IDO), a potent immunosuppressive molecule (2). Evidence also suggests that Nec-1s is around two-times more effective at RIPK1 inhibition than Nec-1 (IC₅₀ = 210 nM vs. 494 nM) (1).

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.

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