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XML generation date: 2024-04-24 09:10:48.917
Product last modified at: 2024-06-05T15:45:08.692Z
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PDP - Template Name: Chemical Modulators
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  1. Products /
  2. Activators & Inhibitors /
  3. Nelfinavir Mesylate

Nelfinavir Mesylate #27793

    Product Information

    Product Usage Information

    Nelfinavir Mesylate is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 753 μl of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 663.9 g/mol
    Purity >98%
    Molecular Formula C32H45N3O4S • CH3SO3H
    CAS 159989-65-8
    Solubility Soluble in DMSO at 70 mg/ml.

    Background

    Nelfinavir Mesylate, also known as AG-1343, is a potent antiviral inhibitor of HIV-1 protease with a Ki value of 2 nM, in vitro (1). This small molecule is an effective antitumor agent, known to induce endoplasmic reticulum (ER) stress, autophagy, and apoptosis in vitro and in vivo (2). Nelfinavir Mesylate has anti-microbial effects on malaria, tuberculosis, and SARS (3). It has also been used in therapies as an antifibrotic agent against pulmonary fibrosis in patients with systemic sclerosis (4). Nelfinavir Mesylate is known to reduce inflammation by activating protein phosphatase 2 (PP2) and blocking MAPK signaling in macrophages (5). Through a novel mechanism of heat shock protein 90 (HSP90) inhibition, Nelfinavir Mesylate selectively inhibits the growth of HER2-positive breast cancer cells in vitro (6).

    Limited Uses

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    Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

    For Research Use Only. Not For Use In Diagnostic Procedures.
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