Niclosamide #69857
Product Information
Product Usage Information
Niclosamide is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 1.02 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
Storage
Product Description
| Molecular Weight | 327.1 g/mol |
| Purity | >98% |
| Molecular Formula | C13H8Cl2N2O4 |
| CAS | 50-65-7 |
| Solubility | Soluble in DMSO at 14 mg/ml or ethanol at 6 mg/ml. |
Background
Niclosamide is a STAT3 inhibitor (IC50 = 0.25 μM) known to induce apoptosis and cell cycle arrest (1). This small molecule stimulates autophagy by reversibly inhibiting mammalian target of rapamycin complex 1 (mTORC1) signaling and inhibiting phosphorylation of ribosomal S6 kinases at certain concentrations (2). In clinical settings, Niclosamide has been used to treat parasitic-driven diseases in humans as an antihelminthic drug. Studies have shown Niclosamide to be an effective antiviral agent, inhibiting the replication of SARS-CoV (3).
Limited Uses
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