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Product last modified at: 2024-07-30T13:00:12.952Z
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  1. Products /
  2. Activators & Inhibitors /
  3. Nonactin

Nonactin #76040

    Product Information

    Product Usage Information

    Nonactin is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 0.68 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 2 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 736.9 g/mol
    Purity >99%
    Molecular Formula C40H64O12
    CAS 6833-84-7
    Solubility Soluble in DMSO at 10 mg/mL or ethanol at 10 mg/mL.

    Background

    The antibiotic Nonactin is an ionophore that binds and transports monovalent cations (e.g., K+, NH4+, and Na+) across membranes through passive diffusion (1). Nonactin displays both antibacterial and anti-tumor activities, and inhibits drug efflux in multiple drug resistant cancers (2). Naturally occurring Nonactin is composed of four monomers of Nonactic acid, comprised of an equal number of (+) and (-) monomers. The antibiotic properties of Nonactin result from its ability to form stable complexes with monovalent cations; artificial Nonactin tetramers, comprised of either all (+) or all (-) Nonactic acid monomers, lack ion binding ability and are less potent antibiotics (3). Treatment of erythrocytes with Nonactin leads to suicidal erythrocyte death as evidenced by the shrinking of erythrocytes and translocation of phosphatidylserine from the erythrocyte interior to the cell surface (4). Nonactin selectively induces apoptosis and results in tumor regression in a β-catenin mutant HCT 116 xenograft model (5), and can inhibit the surface expression of endogenous HSP60 (6).

    Limited Uses

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    Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

    For Research Use Only. Not For Use In Diagnostic Procedures.
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