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Render Timestamp: 2024-12-23T10:52:18.262Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-09-20 06:23:31.574
Product last modified at: 2024-08-30T23:15:07.629Z
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72
  1. Products /
  2. Activators & Inhibitors /
  3. NSC-697923

NSC-697923 #10473

    Product Information

    Product Usage Information

    NSC-697923 is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 1 mg of powder in 0.37 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 267.3 g/mol
    Purity >98%
    Molecular Formula C11H9NO5S
    CAS 343351-67-7
    Solubility Soluble in DMSO at 25 mg/mL or ethanol at 5 mg/mL.

    Background

    NSC-697923 is a small-molecule inhibitor of the E2 ubiquitin-conjugating enzyme Ubc13-Uev1A. NSC-697923 blocked formation of Ubc13 and ubiquitin thioester conjugates, and suppressed constitutive NF-κB activity in diffuse large B cell lymphoma cells. Inhibition of ubiquitin-dependent DNA damage signaling was observed, but not formation of the phosphorylated form of histone variant H2AX, which is consistent with NSC-697923 targeting of nuclear Ubc13 (1). Additional data suggested that NSC-697923 interacted with the Ubc13 active site cysteine (2). UBE2N (Ubc13) is an E2 ubiquitin-conjugating enzyme that catalyzes K63-linked poly-Ub chain formation. UBE2N forms a heterodimer with MMS2 or Uev1A to exert its E2 ligase function (3). NSC-697923 treatment of neuroblastoma cells increased apoptosis and nuclear p53 accumulation, and enhanced tumor suppression (4). NSC-697923 also inhibited caspase-1 enzymatic activity (IC50 = 1.737 μM) and NLRP3 protein expression by suppressing the NF-κB signaling pathway. NSC-697923 inhibited joint swelling and NLRP3 inflammasome activation in an animal model of gouty arthritis (5).

    Limited Uses

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    For Research Use Only. Not For Use In Diagnostic Procedures.
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