Resiquimod (R-848) #83597
Product Information
Product Usage Information
Resiquimod (R-848) is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 1.06 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
Storage
Product Description
| Molecular Weight | 314.4 g/mol |
| Purity | >98% |
| Molecular Formula | C17H22N4O2 |
| CAS | 144875-48-9 |
| Solubility | Soluble in DMSO at 30 mg/ml or ethanol at 15 mg/ml with slight warming. |
Background
Resiquimod (R-848), an antiviral imidazoquinoline, has been shown to activate Toll-like receptor 7 (TLR7) and TLR8 via the MyD88-dependent interleukin 1 receptor (IL-1R)-TLR signaling pathway (1). Triggering of the TLR pathway leads to the activation of NF-κB and subsequent regulation of immune and inflammatory genes (2). Similar to CD40, treatment with Resiquimod (R-848) activates B cells and can induce nuclear translocation of NF-κB at a concentration of 1 μg/ml (3).
Limited Uses
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