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Render Timestamp: 2024-11-01T10:28:18.300Z
Commit: 23cb9f61fe67e1e9093fd644a533c4ff516a6463
XML generation date: 2024-09-20 06:23:31.968
Product last modified at: 2024-08-02T21:15:07.134Z
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72
  1. Products /
  2. Activators & Inhibitors /
  3. Retinoic Acid (Tretinoin)

Retinoic Acid (Tretinoin) #38255

    Product Information

    Product Usage Information

    Retinoic Acid (Tretinoin) is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 1.11 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 300.4 g/mol
    Purity >98%
    Molecular Formula C20H28O2
    CAS 302-79-4
    Solubility Soluble in DMSO at 25 mg/mL or ethanol at 10 mg/mL.

    Background

    The ligand Retinoic Acid (Tretinoin) binds retinoic acid receptors (RARα, RARβ, and RARγ) and retinoid X receptors (RXRα, RXRβ, and RXRγ). RAR-RXR heterodimers and RXR homodimers control gene expression by binding to specific Retinoic Acid response elements, by recruiting cofactors and the transcriptional machinery, and by indirectly regulating chromatin structure (1). Signaling pathways controlled by Retinoic Acid coordinate cell proliferation, differentiation, apoptosis, and development of many organs and tissues (2). Oxidation of vitamin A creates a retinal intermediate which is subsequently oxidized to form Retinoic Acid (3). All-trans retinoic acid (ATRA) is an active metabolite of vitamin A that is used in the treatment of several cancers, including ovarian carcinoma, bladder cancer, neuroblastoma, and Kaposi's sarcoma. ATRA inhibits inflammation in rheumatoid arthritis and inhibits proliferation in vascular smooth muscle cells (4). A topical version of Retinoic Acid (Tretinoin) has long been used to treat acne and the effects of photoaging of the skin (5).

    Limited Uses

    Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.

    Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

    For Research Use Only. Not For Use In Diagnostic Procedures.
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