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PDP - Template Name: Chemical Modulators
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Ribavirin #65085

    Product Information

    Product Usage Information

    Ribavirin is supplied as a lyophilized powder. For a 20 mM stock, reconstitute 5 mg of powder in 1.02 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 244.2 g/mol
    Purity >98%
    Molecular Formula C8H12N4O5
    CAS 36791-04-5
    Solubility Soluble in DMSO at 25 mg/ml or water at 25 mg/ml.

    Background

    Ribavirin is a purine ribonucleoside analogue most widely known for its broad-spectrum anti-viral properties against both RNA and DNA viruses. Ribavirin is capable of mimicking the activity of inosine, guanosine, or adenosine and has mutagenic properties that can cause the disruption of viral genome transcription and translation. The monophosphate metabolite is a competitive inhibitor of inosine monophosphate (IMP) dehydrogenase with a Ki value of 270 nM (1-3). Ribavirin multifariousness enables simultaneous manipulation of both viral and host enzymatic processes and exhibits several immunomodulatory mechanisms including key roles in the mediation of pathways such as ERK, eIF4E, MNK1, EZH2, and MAPK (4,5). Studies have shown that in vitro treatment of Middle East respiratory syndrome coronavirus (MERS-CoV) with Ribavirin and interferon-α2b reduces viral replication, making Ribavirin a compound of interest when studying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (6,7).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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