Roscovitine #9885

Inquiry Info. # 9885

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Product Information

Product Usage Information

Roscovitine [(R) stereoisomer] is supplied as a 1 mg powder. Store at or below -20ºC. Before use, dissolve powder in 143 μl DMSO or MeOH to make a 20 mM stock solution. The suggested working concentration is 20 μM in tissue culture medium. Treat cells for 4-24 hours. Store solution at -20ºC.

Storage

Store lyophilized or in solution at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight	354.45 g/mol
Purity	>99%
Molecular Formula	C₁₉H₂₈N₆O
CAS	186692-46-6
Solubility	Soluble in DMSO and EtOH at 200mg/ml.

Background

Roscovitine is a cell permeable reversible selective inhibitor of cyclin-dependent kinases CDK1 (cdc2), CDK2 and CDK5 (1). A purine analog, this drug competes for the binding site of ATP in the catalytic cleft. Treatment of cultured cells with roscovitine can cause cell cycle arrest or apoptosis (1-4). The IC₅₀ for cdc2 activity is 0.65 μM in vitro (1).

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.

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