Render Target: STATIC
Render Timestamp: 2024-11-21T13:41:13.005Z
Commit: 5c4accf06eb7154018ba3f54329c7590f97f534a
XML generation date: 2024-09-20 06:23:31.831
Product last modified at: 2024-08-30T22:45:07.809Z
View Featured Offers >>
1% for the planet logo
PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72
  1. Products /
  2. Activators & Inhibitors /
  3. Rosiglitazone Maleate

Rosiglitazone Maleate #78946

    Product Information

    Product Usage Information

    Rosiglitazone Maleate is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.06 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at room tempertaure, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 473.5 g/mol
    Purity >98%
    Molecular Formula C18H19N3O3S • C4H4O4
    CAS 155141-29-0
    Solubility Soluble in DMSO at 3 mg/mL or DMF at 10 mg/mL.

    Background

    Rosiglitazone Maleate is an agonist of peroxisome proliferator-activated receptor γ (PPARγ), a ligand-activated nuclear receptor preferentially expressed in adipocytes, vascular smooth muscle cells, and macrophages. Rosiglitazone Maleate mediates adipogenesis, lipid metabolism, and insulin sensitivity (1). Rosiglitazone Maleate binds both PPARγ1 and PPARγ2 isoforms with high affinity. Treatment of mesenchymal stem cells with Rosiglitazone Maleate resulted in adipocyte differentiation (2). The treatment of type 2 diabetes mellitus using Rosiglitazone Maleate is controversial as its use can lead to serious side effects, including myocardial hypertrophy and heart failure (3). Exposure of murine neuroblastoma cells and primary hippocampal neurons to Rosiglitazone Maleate protected these cells from oxidative stress. Rosiglitazone Maleate binding to PPARγ activated transcription of neurotrophic factor-α1 (NF-α1), which promoted increased expression of BCL-2 and inhibition of caspase-3 (4). Studies suggest that Rosiglitazone Maleate prevents microglial activation, promotes microglial anti-inflammatory polarization, and suppresses inflammatory cytokines in inflammation-related diseases. In a mouse model of status epilepticus, Rosiglitazone Maleate prevented microglial activation and inhibited pilocarpine-induced status epilepticus (5).

    Limited Uses

    Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.

    Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

    For Research Use Only. Not For Use In Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
    All other trademarks are the property of their respective owners. Visit our Trademark Information page.