SC-79 #90851

Name: SC-79
Price: 86.00 USD
Availability: InStock

Product Information

Product Usage Information

SC-79 is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 0.91 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 2 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight	364.8 g/mol
Purity	>98%
Molecular Formula	C₁₇H₁₇ClN₂O₅
CAS	305834-79-1
Solubility	Soluble in DMSO at 100 mg/mL or ethanol at 40 mg/mL.

Background

The small-molecule SC-79 activates cytosolic Akt (PKB, protein kinase B) and inhibits Akt translocation to the membrane. Binding of SC-79 to Akt promotes interaction between Akt and the protein kinase PDK1, leading to phosphorylation of Akt at Thr308 and Ser473 (1). In a mouse model of acute liver failure, SC-79 treatment protects hepatocytes from apoptosis by inhibiting Akt-mediated aggregation of Fas and by blocking recruitment of FADD and procaspase-8 into the death-inducing signaling complex (2). Likewise, SC-79 protects hepatocytes from tumor necrosis factor-α (TNF-α)-induced apoptosis and mice from induced liver injury and damage (3). In a rat model of alcohol-induced osteonecrosis, SC-79 exposure leads to activation of cytosolic Akt and attenuation of bone tissue morphological changes (4). SC-79 treatment of neuroblastoma cells and murine dopaminergic neurons leads to Akt activation and protection from hydrogen peroxide-induced apoptosis and necrosis (5).

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.

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