SM-164 #56003

Name: SM-164
Price: 183.00 USD
Availability: InStock

Product Information

Product Usage Information

SM-164 is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 1 mg of powder in 89 μL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight	1121.4 g/mol
Purity	>98%
Molecular Formula	C₆₂H₈₄N₁₄O₆
CAS	957135-43-2
Solubility	Soluble in DMSO at 50 mg/mL.

Background

SM-164 is a bivalent, cell-permeable, non-peptide, SMAC mimetic and potent XIAP inhibitor with an IC₅₀ value of 1.39 nM. SM-164 binds to the BIR2 and BIR3 domains of XIAP and effectively inhibits cell growth and induces apoptosis in HL-60 leukemia cells (1). It also activates caspase-3 and caspase-9 that, in turn, induce apoptosis in leukemia cells (1,2). In breast cancer mouse xenograft models, SM-164 in combination with TNF-related apoptosis-inducing ligand (TRAIL) has been shown to reduce tumor volume by 80%. SM-164 is an effective apoptotic inducer of tumor cells and tissues and is a promising candidate for a new class of anticancer drugs (2). Treatment of RIP3-positive cells with SM-164 in combination with TNF-alpha and the caspase inhibitor Z-VAD, leads to necroptosis (3).

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.

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