SM-164 #56003
Product Information
Product Usage Information
Storage
Product Description
| Molecular Weight | 1121.4 g/mol |
| Purity | >98% |
| Molecular Formula | C62H84N14O6 |
| CAS | 957135-43-2 |
| Solubility | Soluble in DMSO at 50 mg/mL. |
Background
SM-164 is a bivalent, cell-permeable, non-peptide, SMAC mimetic and potent XIAP inhibitor with an IC50 value of 1.39 nM. SM-164 binds to the BIR2 and BIR3 domains of XIAP and effectively inhibits cell growth and induces apoptosis in HL-60 leukemia cells (1). It also activates caspase-3 and caspase-9 that, in turn, induce apoptosis in leukemia cells (1,2). In breast cancer mouse xenograft models, SM-164 in combination with TNF-related apoptosis-inducing ligand (TRAIL) has been shown to reduce tumor volume by 80%. SM-164 is an effective apoptotic inducer of tumor cells and tissues and is a promising candidate for a new class of anticancer drugs (2). Treatment of RIP3-positive cells with SM-164 in combination with TNF-alpha and the caspase inhibitor Z-VAD, leads to necroptosis (3).
Limited Uses
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