Render Target: STATIC
Render Timestamp: 2024-11-28T11:29:33.554Z
Commit: d79925545b26f8827f92d145dadc6f0527debdb1
XML generation date: 2024-09-19 21:57:41.918
Product last modified at: 2024-11-11T15:15:10.728Z
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72

Stattic #97598

    Product Information

    Product Usage Information

    Stattic is supplied as a lyophilized powder. For a 40 mM stock, reconstitute 10 mg of powder in 1.18 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 211.2 g/mol
    Purity >98%
    Molecular Formula C8H5NO4S
    CAS 19983-44-9
    Solubility Soluble in DMSO at 10 mg/ml or ethanol at 1 mg/ml.

    Background

    Stattic is a nonpeptidic selective Stat3 inhibitor. This small molecule prevents the binding of tyrosine-phosphorylated peptide motifs to the Stat3 SH2 domain, inhibiting Stat3 activation, dimerization, and nuclear translocation with an IC50 value of 5.1 μM (incubated for 1 hour at 37°C) (1). Stattic blocks IL-6-induced Stat3 activation, reducing cell viability in tumor cells (2). Treatment with 10 μM induces apoptosis in Stat3-dependent cancer cell lines MDA-MB-231 and MDA-MB-435S (1).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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