Talazoparib #80577
Product Information
Product Usage Information
Storage
Product Description
| Molecular Weight | 380.4 g/mol |
| Purity | >97% |
| Molecular Formula | C19H14F2N6O |
| CAS | 1207456-01-6 |
| Solubility | Soluble in DMSO at 20 mg/mL. |
Background
Talazoparib (BMN 673) is a potent, selective PARP inhibitor with an IC50 value for PARP1 of 0.57 nM. It can inhibit both PARP1 and PARP2, but not PARG. Talazoparib selectively targets tumor cells with BRCA1, BRCA2, and PTEN gene mutations. It is effective in inducing antitumor activity in vivo in xenografted tumors from mice (1).
Limited Uses
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