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Render Timestamp: 2024-12-26T11:05:42.825Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-09-20 06:23:26.684
Product last modified at: 2024-12-17T19:02:23.847Z
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PDP - Template Name: Chemical Modulators
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  1. Products /
  2. Activators & Inhibitors /
  3. Thalidomide

Thalidomide #83687

    Product Information

    Product Usage Information

    Thalidomide is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 1.29 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Caution: Teratogenic. Pregnant women should avoid using this compound.

    Storage

    Store lyophilized at room temperature, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 258.2 g/mol
    Purity >98%
    Molecular Formula C13H10N2O4
    CAS 50-35-1
    Solubility Soluble in DMSO at 5 mg/mL.

    Background

    Thalidomide was briefly used as an antiemetic and sedative to treat “morning sickness,” anxiety, and insomnia before being removed from the market due to its association with neonatal mortality and severe birth defects. It reentered the clinical marketplace decades later as an antiangiogenic and anti-inflammatory agent effective against several forms of cancer, leprosy, and some inflammatory disorders (1,2). Thalidomide and its analogs, Lenalidomide and Pomalidomide, are immunomodulatory drugs that bind the CRL4 E3 ubiquitin ligase substrate receptor Cereblon (CRBN) to promote the ubiquitination and targeted degradation of several transcription factors. These compounds target several proteins, including C2H2 zinc finger transcription factors Ikaros, Aiolos, and ZFP91, as well as casein kinase 1α, to control a broad transcriptional network (3,4). Thalidomide can also downregulate the zinc finger transcription factor SALL4, which is implicated in some human malformation syndromes, including Duane-radial ray syndrome (Okihiro syndrome) and Acro-renal-ocular syndrome (5).

    Limited Uses

    Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.

    Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

    For Research Use Only. Not For Use In Diagnostic Procedures.
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