Triptolide #97539
Product Information
Product Usage Information
Triptolide is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.38 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
Storage
Product Description
| Molecular Weight | 360.4 g/mol |
| Purity | >98% |
| Molecular Formula | C20H24O6 |
| CAS | 38748-32-2 |
| Solubility | Soluble in DMSO at 7 mg/ml. |
Background
Triptolide is an immunosuppressive and anti-inflammatory compound produced by the thunder god vine, Tripterygium wilfordii Hook F (1). Covalent binding of Triptolide to human XPB/ERCC3 inhibits its DNA-dependent ATPase activity and prevents nucleotide excision repair by the TFIIH complex (2). Triptolide has proven to be an effective synergistic therapy for inhibition of pancreatic cancer cell growth, with IC50 values of 0.01 µM and 0.02 µM in Capan-1 and Capan-2 adenocarcinoma cells, respectively (3,4). In addition to its anti-tumor activity, Triptolide has shown antiviral efficacy in HIV-1 and dengue virus via inhibition of Tat protein and COX-2, respectively (5,6).
Limited Uses
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