Triptolide #97539

Name: Triptolide
Price: 139.00 USD
Availability: InStock

Product Information

Product Usage Information

Triptolide is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.38 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight	360.4 g/mol
Purity	>98%
Molecular Formula	C₂₀H₂₄O₆
CAS	38748-32-2
Solubility	Soluble in DMSO at 7 mg/ml.

Background

Triptolide is an immunosuppressive and anti-inflammatory compound produced by the thunder god vine, Tripterygium wilfordii Hook F (1). Covalent binding of Triptolide to human XPB/ERCC3 inhibits its DNA-dependent ATPase activity and prevents nucleotide excision repair by the TFIIH complex (2). Triptolide has proven to be an effective synergistic therapy for inhibition of pancreatic cancer cell growth, with IC₅₀ values of 0.01 µM and 0.02 µM in Capan-1 and Capan-2 adenocarcinoma cells, respectively (3,4). In addition to its anti-tumor activity, Triptolide has shown antiviral efficacy in HIV-1 and dengue virus via inhibition of Tat protein and COX-2, respectively (5,6).

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.

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