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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72
  1. Products /
  2. Activators & Inhibitors /
  3. UNC-2170 Hydrochloride

UNC-2170 Hydrochloride #47412

    Product Information

    Product Usage Information

    UNC-2170 Hydrochloride is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 0.95 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 349.7 g/mol
    Purity >98%
    Molecular Formula C14H21BrN2O • HCl
    CAS 1648707-58-7
    Solubility Soluble in DMSO at 40 mg/mL or water at 50 mg/mL.

    Background

    UNC-2170 Hydrochloride is a small-molecule inhibitor of p53-binding protein 1 (53BP1), a protein involved in DNA damage response. By screening a set of methyl-lysine binding proteins, UNC-2170 was identified as a fragment-like ligand that preferentially binds 53BP1 (1). 53BP1 is a methyl-lysine binding protein recruited to double-strand DNA breaks, playing a central role in DNA damage repair by promoting non-homologous end joining (NHEJ) repair (2). The 53BP1 protein contains a tandem tudor domain responsible for the recognition and binding of methylated lysine residues on histone proteins. Because UNC-2170 binds the same 53BP1 domain recognized by histones (Kd = 22 ± 2.5 µM), UNC-2170 competes for histone binding and functions as a 53BP1 antagonist in cellular lysates (1). UNC-2170 is only a modestly potent inhibitor of 53BP1 protein function; UNC-2170 analogs and other compounds that bind and inhibit 53BP1 are under development (3).

    Limited Uses

    Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.

    Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

    For Research Use Only. Not For Use In Diagnostic Procedures.
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