Valinomycin #49615
Product Information
Product Usage Information
Valinomycin is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 10 mg of powder in 900 μl of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
Storage
Product Description
| Molecular Weight | 1111.3 g/mol |
| Purity | >98% |
| Molecular Formula | C54H90N6O18 |
| CAS | 2001-95-8 |
| Solubility | Soluble in DMSO at 25 mg/ml or ethanol at 25 mg/ml. |
Background
Valinomycin, also known as NSC 122023, is a naturally occurring antibiotic consisting of a cyclized dodecadepsipeptide isolated from various strains of the genus Streptomyces. Valinomycin is a highly selective potassium ionophore that transports K+ across lipid membranes inducing cell death through depolarization of the mitochondrial membrane (1). Studies have investigated the critical role of potassium in viral infections (2). Valinomycin has demonstrated the ability to block viral fusion with endosomal membranes, affecting viral transcription and inhibiting viral replication, by collapsing the membrane potential (3,4). Research studies of severe acute respiratory syndrome (SARS) viral replication in Vero E6 cells identified Valinomycin as the most potent inhibitor (EC50 = 0.85 μM) as compared with other possible treatments, such as Reserpine (EC50 = 3.4 μM) and Aescim (EC50 = 6.0 μM) (5).
Limited Uses
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