Verteporfin #64260
Product Information
Product Usage Information
Storage
Product Description
| Molecular Weight | 718.8 g/mol |
| Purity | >98% |
| Molecular Formula | C41H42N4O8 |
| CAS | 129497-78-5 |
| Solubility | Soluble in DMSO at 14 mg/mL. |
Background
Verteporfin is a benzoporphyrin derivative that is photoactivated by nonthermal red light in the presence of oxygen. It is used clinically as a photosensitizer in photodynamic therapy to treat selected vascular-related diseases. When photoactivated in vasculature, verteporfin generates reactive oxygen species that induce localized damage to endothelial cells, resulting in targeted vessel blockage. Established clinical uses of verteporfin include the treatment of age-related macular degeneration, subfoveal choroidal neovascularization, and pathological myopia (1,2); its anti-angiogenic effects have also led to its consideration as an anti-tumor agent (3). However, the cellular effects of verteporfin exposure extend beyond its photosensitizing activity. It has also been shown to block the interaction between the transcriptional co-activator YAP and TEAD family transcription factors, notably in the absence of photoactivation. This was shown to result in transcriptional repression of YAP target genes that regulate cell proliferation and cell death (4,5), suggesting an additional mechanism by which verteporfin could be utilized as an anti-tumor agent.
Limited Uses
Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.
Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.