WHI-P131 #29832
Product Information
Product Usage Information
WHI-P131 is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 998 μl of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
Storage
Product Description
| Molecular Weight | 333.8 g/mol |
| Purity | >98% |
| Molecular Formula | C16H15N3O3 • HCl |
| CAS | 202475-60-3 |
| Solubility | Soluble in DMSO at 50 mg/ml. |
Background
WHI-P131 is a potent and selective inhibitor of Janus kinase 3 (Jak3) (IC50 = 78 μM) and glioblastoma cell adhesion and migration (1,2). This novel quinazoline derivative inhibits the enzymatic activity of constitutively active Jak3 without affecting Jak1, Jak2, or other family tyrosine kinases (1). WHI-P131 has also been shown to inhibit thrombin-induced tyrosine phosphorylation of Stat1 and Stat3. These properties make this compound useful when studying different diseases such as acute lymphoblastic leukemia, glioblastoma multiforme, and thromboembolism (1-3).
Limited Uses
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