CD206/MRC1 (E2L9N) Rabbit mAb (Alexa Fluor® 647 Conjugate) #74691
- IHC
Supporting Data
REACTIVITY | H |
SENSITIVITY | Endogenous |
MW (kDa) | |
Source/Isotype | Rabbit IgG |
Application Key:
- IHC-Immunohistochemistry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Description
Product Usage Information
Application | Dilution |
---|---|
Immunohistochemistry (Paraffin) | 1:50 - 1:200 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Monoclonal antibody is produced by immunizing animals with recombinant human CD206/MRC1 protein.
Background
The mannose receptor (MR/CLEC13D/CD206/MMR/MRC1/Macrophage mannose receptor 1) is an endocytic receptor expressed by populations of dendritic cells, macrophages, and nonvascular endothelium (1). The mannose receptor is a heavily glycosylated type I transmembrane protein with three types of extracellular domains and a short carboxy-terminal cytoplasmic domain with no apparent signaling motif (2-4). The extracellular portion of the protein is made up of a CR domain, which binds sulfated glycans, an FNII domain, which binds collagens, and eight C-type lectin domains, which bind carbohydrates containing mannose, fucose, or GlcNAc (4-7). The receptor recycles between the plasma membrane and early endosomes (8). Functions include a role in antigen cross-presentation, clearance of endogenous proteins, pathogen detection, and trafficking through lymphatic vessels (9-12).
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- Wileman, T.E. et al. (1986) Proc Natl Acad Sci U S A 83, 2501-5.
- Taylor, M.E. et al. (1990) J Biol Chem 265, 12156-62.
- Fiete, D.J. et al. (1998) Proc Natl Acad Sci U S A 95, 2089-93.
- Napper, C.E. et al. (2006) Biochem J 395, 579-86.
- Fiete, D. et al. (1997) Proc Natl Acad Sci U S A 94, 11256-61.
- Tietze, C. et al. (1982) J Cell Biol 92, 417-24.
- Burgdorf, S. et al. (2006) J Immunol 176, 6770-6.
- Lee, S.J. et al. (2002) Science 295, 1898-901.
- Milone, M.C. and Fitzgerald-Bocarsly, P. (1998) J Immunol 161, 2391-9.
- Marttila-Ichihara, F. et al. (2008) Blood 112, 64-72.
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