CXCR5 (E3G3A) Rabbit mAb (Alexa Fluor® 647 Conjugate) #67145
- F
Supporting Data
| REACTIVITY | M |
| SENSITIVITY | Endogenous |
| MW (kDa) | |
| Source/Isotype | Rabbit IgG |
Application Key:
- F-Flow Cytometry
Species Cross-Reactivity Key:
- M-Mouse
Product Information
Product Description
Product Usage Information
| Application | Dilution |
|---|---|
| Flow Cytometry (Live) | 1:50 |
Storage
Protocol
Specificity / Sensitivity
CXCR5 (E3G3A) Rabbit mAb (Alexa Fluor® 647 Conjugate) recognizes endogenous levels of total CXCR5 protein.
Species Reactivity:
Mouse
Source / Purification
Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the extracellular domain of mouse CXCR5 protein.
Background
CXCR5 is a G protein-coupled receptor belonging to the chemokine receptor subfamily (1). Upon binding of its ligand, the chemokine CXCL13, CXCR5 initiates multiple intracellular signaling pathways that regulate cell proliferation, survival, and migration (2). CXCR5 is expressed in both mature B cells and follicular helper T cells, and responds to CXCL13 gradient to control lymphocyte migration toward secondary lymphoid tissues (3). CXCR5 has also been shown to be highly expressed in primary breast tumors, in correlation with their propensity to grow and metastasize (4).
Limited Uses
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