GATA-1 (D52H6) XP® Rabbit mAb (Alexa Fluor® 647 Conjugate) #89084
- IF
- F
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | |
| Source/Isotype | Rabbit IgG |
Application Key:
- IF-Immunofluorescence
- F-Flow Cytometry
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Description
Product Usage Information
| Application | Dilution |
|---|---|
| Immunofluorescence (Immunocytochemistry) | 1:50 - 1:200 |
| Flow Cytometry (Fixed/Permeabilized) | 1:100 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
GATA-1 is the founding member of the GATA family and is required for erythroid and megakaryocytic cell development (4,5). Mutations in the corresponding GATA-1 gene are linked to many human diseases, including acute megakaryoblastic leukemia in Down Syndrome children (DS-AMKL), X-linked thrombocytopenia, and gray platelet syndrome (6-9).
- Ko, L.J. and Engel, J.D. (1993) Mol Cell Biol 13, 4011-22.
- Merika, M. and Orkin, S.H. (1993) Mol Cell Biol 13, 3999-4010.
- Lowry, J.A. and Atchley, W.R. (2000) J Mol Evol 50, 103-15.
- Pevny, L. et al. (1991) Nature 349, 257-60.
- Fujiwara, Y. et al. (1996) Proc Natl Acad Sci U S A 93, 12355-8.
- Wechsler, J. et al. (2002) Nat Genet 32, 148-52.
- Cantor, A.B. (2005) Int J Hematol 81, 378-84.
- Mehaffey, M.G. et al. (2001) Blood 98, 2681-8.
- Tubman, V.N. et al. (2007) Blood 109, 3297-9.
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