Render Target: STATIC
Render Timestamp: 2025-01-07T12:29:19.196Z
Commit: 199712eb9daea12d88cc0e67894a8a09f475f8cb
XML generation date: 2024-10-22 22:01:09.260
Product last modified at: 2025-01-01T09:11:17.781Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

NKX2.5 (E1Y8H) Rabbit mAb (Alexa Fluor® 647 Conjugate) #40617

Filter:
  • F

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa)
    Source/Isotype Rabbit IgG
    Application Key:
    • F-Flow Cytometry 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Description

    This Cell Signaling Technology® antibody is conjugated to Alexa Fluor® 647 fluorescent dye under optimal conditions. This antibody is expected to exhibit the same species cross-reactivity as the unconjugated NKX2.5 (E1Y8H) Rabbit mAb #8792.

    Product Usage Information

    Application Dilution
    Flow Cytometry (Fixed/Permeabilized) 1:50

    Storage

    Supplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.

    Protocol

    Specificity / Sensitivity

    NKX2.5 (E1Y8H) Rabbit mAb (Alexa Fluor® 647 Conjugate) recognizes endogenous levels of total NKX2.5 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro67 of human NKX2.5 protein.

    Background

    The NKX family of homeobox genes are known to act as intermediaries in the neural response to Sonic hedgehog signaling during central nervous system (CNS) development (1). NKX2.2 is a member of this family of transcription factors and is necessary for neuroendocrine differentiation in the CNS and pancreas (2,3). NKX2.2 mutant mice die shortly after birth due to incomplete differentiation of insulin-producing pancreatic β cells and defects in ventral neural patterning (2,3). According to the research literature, expression of NKX2.2 has also been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors (4).
    For Research Use Only. Not For Use In Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
    Alexa Fluor is a registered trademark of Life Technologies Corporation.
    This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or [email protected].
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