Tox2 (E3N3G) Rabbit mAb (Alexa Fluor® 488 Conjugate) #65874
- IF
- F
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | |
| Source/Isotype | Rabbit IgG |
Application Key:
- IF-Immunofluorescence
- F-Flow Cytometry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Description
Product Usage Information
| Application | Dilution |
|---|---|
| Immunofluorescence (Immunocytochemistry) | 1:800 |
| Flow Cytometry (Fixed/Permeabilized) | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Tox2 is expressed by natural killer (NK) cells, T follicular helper (Tfh) cells, and exhausted CD8+ T cells (3,4). Tox2 and BCL6 play a critical role in Tfh cell development by generating a transcriptional feed-forward loop that drives the Tfh program (5). Tox2 induction plays a role in driving CD8+ T cell exhaustion and is being investigated as a therapeutic target for cancer immunotherapy (6).
- O'Flaherty, E. and Kaye, J. (2003) BMC Genomics 4, 13.
- Aliahmad, P. et al. (2012) Curr Opin Immunol 24, 173-7.
- Vong, Q.P. et al. (2014) Blood 124, 3905-13.
- Han, J. et al. (2022) Clin Exp Immunol 208, 268-280.
- Xu, W. et al. (2019) Immunity 51, 826-839.e5.
- Seo, H. et al. (2019) Proc Natl Acad Sci USA 116, 12410-12415.
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