Human β-Nerve Growth Factor (hβ-NGF) #5221
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Inquiry Info. # 5221
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Product Information
Formulation
Storage
Maintain sterility. Storage at -20°C should be in a manual defrost freezer.
Product Description
| MW (kDa) | 13 |
| Purity | >98% as determined by SDS-PAGE of 6 μg reduced (+) and non-reduced (-) recombinant hβ-NGF. All lots are greater than 98% pure. |
| Endotoxin | Less than 0.01 ng endotoxin/1 μg hβ-NGF. |
| Activity | The bioactivity of recombinant hβ-NGF was determined in a TF-1 cell proliferation assay. The ED50 of each lot is between 0.5-1.5 ng/ml. |
| Molecular Formula | Based on amino acid sequencing, greater than 85% of recombinant hβ-NGF starts at Ser122 (SSSHP) and has a calculated MW of 13,494. The remainder starts at Ser124 (SHPIF). DTT-reduced and non-reduced protein migrate as 13 kDa non-disulfide linked homodimers. |
Source / Purification
Background
- Bibel, M. and Barde, Y.A. (2000) Genes Dev 14, 2919-37.
- Huang, E.J. and Reichardt, L.F. (2003) Annu Rev Biochem 72, 609-42.
- Frossard, N. et al. (2004) Eur J Pharmacol 500, 453-65.
- Jiang, Y. et al. (2007) J Immunol 179, 6297-304.
- Matrone, C. et al. (2009) Proc Natl Acad Sci USA 106, 11358-63.
- Matrone, C. et al. (2008) Proc Natl Acad Sci USA 105, 13139-44.
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