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Human FGF-6 Recombinant Protein #74782

Human FGF-6 Recombinant Protein: Image 1
Serial dilutions of Human FGF-6 Recombinant Protein were added to NR6R-3T3 cells. Cell proliferation was measured and the linear portion of the curve was used to calculate the ED50.

To Purchase # 74782

Cat. #

Size

74782S
25 µg

Product Information

Storage

Human FGF-6 Recombinant Protein is supplied as lyophilized material that is very stable at -20°C. It is recommended to reconstitute with sterile water at a concentration of 0.1 mg/mL which can be further diluted in aqueous solutions as needed. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage.

Once in solution, store at 4°C and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles if storing reconstituted material at -20ºC to -80ºC.

Product Description

MW (kDa) 18.9
Purity A greater than or equal to 95% purity was determined by SDS-PAGE.
Endotoxin Endotoxin levels are less than or equal to 1 EU / 1 μg hFGF-6.
Activity The bioactivity of recombinant hFGF-6 was determined in an NR6R-3T3 cell proliferation assay. The ED50 of each lot is less than or equal to 1 ng/mL.

Source / Purification

Recombinant human FGF-6 was expressed in E. coli and is supplied in a lyophilized form.

Background

FGF-6 is a member of the large and diverse fibroblast growth factor (FGF) family of peptide growth factors. FGF-6 binds to receptor FGFR4 and functions as a signaling molecule that is involved in many important processes (1,2). The mouse homolog of this gene exhibits predominantly in the myogenic lineage which suggests a role in muscle regeneration or differentiation (3,4). FGF-6 was able to transform NIH/3T3 cells and the resulting transformant formed a well-vascularized tumor in nude mice, thus suggesting an angiogenic property similar to some other members of the FGF family (4).
For Research Use Only. Not For Use In Diagnostic Procedures.
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