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Product last modified at: 2024-12-11T09:00:10.864Z
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PDP - Template Name: Growth Factors and Cytokines
PDP - Template ID: *******9ad1159

Human IL-23 Recombinant Protein #16388

    Product Information

    Storage

    Recombinant human IL-23 is supplied as lyophilized material that is very stable at -20ºC. It is recommended to reconstitute with sterile water at a concentration of 0.1 mg/mL which can be further diluted in aqueous solutions as needed. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage.

    Once in solution, store at 4ºC and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles if storing reconstituted material at -20ºC to -80ºC.

    Product Description

    MW (kDa) 63
    Purity A greater than 95% purity was determined by SDS-PAGE.
    Endotoxin Endotoxin levels are less than 1 EU / 1 μg hIL-23.
    Activity The bioactivity of hIL-23 was determined by its ability to induce IL-17 secretion by mouse CTLL-2 cells. The ED50 of each lot is 2.324 ng/mL.

    Source / Purification

    Recombinant human IL-23 was expressed in 293 cells with a C-terminal His-tag and is supplied in a lyophilized form.

    Background

    Interleukin-23 (IL-23) is composed of an IL-12B subunit and an IL-23A subunit, making it a heterodimeric cytokine (1). IL-23 is a known inflammatory cytokine and acts as a mediator responsible for Th17 differentiation and its secretion of IL-17 (2). As a member of the IL-12 cytokine family, IL-23 is known to be involved in autoimmune disorders, including psoriasis and arthritis, as well as several gastric-related autoimmune disorders (3). It has also been shown to induce IFN-γ production and NK cell activation and is a dominant cytokine involved in controlling inflammation in peripheral tissues and joints (4).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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