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Human Interferon-α (IFN-α)

Human Interferon-α (IFN-α) #9906

Inquiry Info. # 9906

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Product Information

Storage

Stable in lyophilized state at 4°C for 1 year after receipt. Sterile stock solutions reconstituted with carrier protein are stable at 4°C for 2 months and at -20°C for 6 months. Avoid repeated freeze-thaw cycles. Maintain sterility. Storage at -20°C should be in a manual defrost freezer.

Source / Purification

Purity: 97.5%

Directions for Use: Human Interferon-alpha (IFN-alpha) is supplied as a solution. It should be stored at -80 degrees Centigrade. Aliquot the reagent upon receipt and avoid repeated freeze-thaw cycles.

Background

Interferons (IFNs) appear both locally and systematically early after viral infection and participate in limiting the spread of infection. They also affect cell differentiation, growth, surface antigen expression, and immunoregulation (1). There are three naturally occurring interferons: α, β, and γ. IFN-α is derived from lymphoblastic tissue and has a number of therapeutic applications in the treatment of various human cancers and diseases of viral origin. Recombinant IFN-α from both natural and synthetic genes binds to a common cell surface receptor and induces antiviral activity in a variety of cell lines. When binding to discrete cell surface receptors on target cells, IFN-α induces rapid changes in Jak/Stat phosphorylation, which initiates the Jak/Stat signaling pathway (2). IFN-α signaling also involves production of DAG without an increased intracellular free calcium concentration and the subsequent activation of calcium-independent isoforms of PKC (β and ε) (3). All IFN-α signaling pathways lead to final alterations of gene expression, which mediate their pleiotropic biologic activities.

Database Links

UniProt ID: P01562

Entrez-Gene Id: 3439

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.

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