Human Neurotrophin-4 (hNT-4) #5592
Inquiry Info. # 5592
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Product Information
Formulation
Storage
Maintain sterility. Storage at -20°C should be in a manual defrost freezer.
Product Description
| MW (kDa) | 14 |
| Purity | >98% as determined by SDS-PAGE of 6 μg reduced (+) and non-reduced (-) recombinant hNT-4. All lots are greater than 98% pure. |
| Endotoxin | Less than 0.01 ng endotoxin/1 μg hNT-4. |
| Activity | The activity of hNT-4 was assessed by quatification of phospho-TrkB in TrkB transfected NIH/3T3 cells. The observed ED50 values are between 1-4 ng/ml. |
| Molecular Formula | Recombinant hNT-4 does not have a Met on the amino terminus and has a calculated MW of 13,923. DTT-reduced and non-reduced protein migrate as 14 kDa polypeptides. The expected amino-terminal GVSET of recombinant hNT-4 was verified by amino acid sequencing. |
Source / Purification
Background
- Ip, N.Y. et al. (1992) Proc Natl Acad Sci U S A 89, 3060-4.
- Vanhecke, E. et al. (2011) Clin Cancer Res 17, 1741-52.
- Moalem, G. et al. (2000) J Autoimmun 15, 331-45.
- Laurenzi, M.A. et al. (1998) J Leukoc Biol 64, 228-34.
- Truzzi, F. et al. (2008) J Invest Dermatol 128, 2031-40.
- Conover, J.C. et al. (1995) Nature 375, 235-8.
- Liu, X. et al. (1995) Nature 375, 238-41.
- Xie, C.W. et al. (2000) Proc Natl Acad Sci U S A 97, 8116-21.
Limited Uses
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