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XML generation date: 2024-10-16 17:30:25.411
Product last modified at: 2024-09-19T08:00:15.398Z
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PDP - Template Name: Growth Factors and Cytokines
PDP - Template ID: *******9ad1159
  1. Products /
  2. Cytokines & Growth Factors /
  3. Human VEGF-121 Recombinant Protein

Human VEGF-121 Recombinant Protein #38285

    Product Information

    Storage

    Human VEGF-121 Recombinant Protein is supplied as lyophilized material that is very stable at -20ºC. It is recommended to reconstitute with sterile water at a concentration of 0.1 mg/mL which can be further diluted in aqueous solutions as needed. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage.

    Once in storage, store at 4ºC and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles if storing reconstituted material at -20ºC to -80ºC.

    Product Description

    MW (kDa) 14.2/28.4
    Purity A greater than or equal to 95% purity was determined by SDS-PAGE.
    Endotoxin Endotoxin levels are less than or equal to 0.1 EU / 1 μg hVEGF-121.
    Activity The bioactivity of recombinant hVEGF-121 was determined in a HUVEC proliferation assay. The ED50 of each lot is less than or equal to 5 ng/mL.

    Source / Purification

    Recombinant human VEGF-121 was expressed in E. coli and is supplied in a lyophilized form.

    Background

    VEGF121 is the second most abundant splice variant of vascular endothelial growth factor-A (VEGF-A; formerly VEGF) (1,2). VEGF121 is produced by endothelial cells, macrophages, T cells, and other cell types. VEGF121 is involved in angiogenesis, vascular endothelial cell survival, growth, migration, and vascular permeability (1). VEGF121 expression is induced by hypoxia, inflammatory cytokines, and through oncogene products in tumors (1-3). VEGF121 binds to VEGFR1 and VEGFR2 receptor tyrosine kinases (1). Binding of VEGF121 to VEGFR1 and VEGFR2 leads to activation of pathways involving PI3K/Akt, p38 MAPK, and FAK (1). VEGF plays a key role in tumor angiogenesis in many cancers (2).

    Database Links

    UniProt ID: P15692-1


    Entrez-Gene Id: 7422


    Limited Uses

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    Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

    For Research Use Only. Not For Use In Diagnostic Procedures.
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